WHO says Remdesivir didn’t cut hospital stay or mortality in Covid-19 patients

WHO says Remdesivir didn’t cut hospital stay or mortality in Covid-19 patients. A clinical trial by the World Health Organization (WHO) has discovered that remdesivir had little or no effect on Covid-19 patients’ length of hospital stay or odds of endurance.

A ‘Solidarity’ trial by the WHO evaluated the effects of four potential drug regimens – remdesivir, hydroxychloroquine, anti-HIV drug combination lopinavir/ritonavir and interferon – in 11,266 adult patients across more than 30 countries.

The study found the regimens appeared to have little or no effect on 28-day mortality or the length of the in-hospital course among patients hospitalized with Covid-19, the WHO was quoted as saying by Reuters. The results of the trial are yet to be reviewed.

The antiviral medication, among the first to be used as a treatment for Covid-19, was one of the drugs recently used to treat US President Donald Trump’s coronavirus infection.

‘Data appears inconsistent’

Earlier this month, data from a US study of remdesivir by Gilead showed the treatment cut Covid-19 recovery time by five days compared with patients who got a placebo in a trial comprising 1,062 patients.

“The developing (WHO) data appears inconsistent, with more robust evidence from multiple randomized, controlled studies published in peer-reviewed diaries validating the clinical benefit of remdesivir,” Gilead told Reuters.

“We are concerned the data from this open-label global trial has not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design.”

What next?

WHO chief scientist Soumya Swaminathan said on Wednesday that during the study, hydroxychloroquine and lopinavir/ritonavir were stopped in June after they proved ineffective, but other trials continued in more than 500 hospitals and 30 countries.

“We’re taking a gander at what’s next. We’re taking a gander at monoclonal anti-bodies, we’re taking a gander at immunomodulators and some of the more current anti-viral drugs that have been developed in the last hardly any months,” Swaminathan said.

Remdesivir received emergency use authorization from the US Food and Drug Administration on May 1, and has since been authorized for use in several countries.

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